Toxicokinetics of phenobarbital in rats with DL-ethionine-induced liver injury.
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چکیده
منابع مشابه
Toxicokinetics of phenobarbital in rats with DL-ethionine-induced liver injury.
The toxicokinetic parameters of phenobarbital (PB) were assessed in a female rat model of liver disease. In a preliminary study to determine the optimum dose of DL-ethionine (ET) for creating liver damage, intraperitoneal injection of 250, 500, or 1,000 mg/kg of ET was done for 4 days. ET treatment caused an increase in serum GOT and GPT activity and a decrease in the serum glucose concentratio...
متن کاملEffects of phenobarbital on drug metabolizing enzyme activities and other biochemical parameters in rats with DL-ethionine-induced liver injury.
Phenobarbital (PB) was orally administered once at a dose of 100 mg/kg to the liver injury model rats treated with DL-ethionine (ET), and the effects of PB on the liver drug metabolizing enzymes (DME) were chiefly examined. Liver weight, liver microsomal protein content, liver aniline 4-hydroxylase (ANH) activity, and aminopyrine N-dimethylase (AMD) activity were markedly increased in the ET-tr...
متن کاملFormation of S-adenosylethionine in liver of rats chronically fed with DL-ethionine.
The early changes in the metabolism of L-ethionine were examined in rats preexposed to chronic administration of DL-ethionine. The capacity of liver to accumulate S-adenosylethionine after a single injection of L-ethionine decreases rapidly from the onset of the carcinogenic regimen. This drop is caused by diminished S-adenosylethionine synthesis, a consequence of lower activity of the ATP-L-me...
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15 صفحه اولEffects of DL-ethionine on mouse liver tRNA base composition.
Treatment of mice with DL-ethionine and adenine causes a reduction of all methylated bases of liver tRNA. This effect is dose-dependent and specific for the methylated bases. Individual methylated components are affected to different extents, m22G being most sensitive to inhibition.
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 1993
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.18.4_245